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nrf2 specific inhibitor ml385  (Macklin Inc)

 
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    Macklin Inc nrf2 specific inhibitor ml385
    Nrf2 Specific Inhibitor Ml385, supplied by Macklin Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nrf2 specific inhibitor ml385/product/Macklin Inc
    Average 90 stars, based on 1 article reviews
    nrf2 specific inhibitor ml385 - by Bioz Stars, 2026-02
    90/100 stars

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    Fig. 8. <t>ML385</t> eliminated the protective effects of notoginsenoside R1 in HAMI rats myocardial damage. (A) Myocardial injury was assessed by H&E staining (n=4). Blue arrow represents break-up of myocardial fibers; black arrow represents myocardial hemorrhage; and the green arrow represents inflammatory cells. Original magnification: ×20 (upper row); ×40 (lower row). Bar = 50 µm. (B) Ttransmission electron microscopy was applied to visualize changes in the organelles in cardiomyocytes (CMF, cardiac muscle fibers; Mi, mitochondria). Blue arrow represents break-up of myocardial fibers; red arrow represents mitochondrial changes of ferroptosis; and the yellow arrow represents expanded endoplasmic reticulum. Original magnification: ×12,000. Bar = 1 µm.
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    Fig. 8. <t>ML385</t> eliminated the protective effects of notoginsenoside R1 in HAMI rats myocardial damage. (A) Myocardial injury was assessed by H&E staining (n=4). Blue arrow represents break-up of myocardial fibers; black arrow represents myocardial hemorrhage; and the green arrow represents inflammatory cells. Original magnification: ×20 (upper row); ×40 (lower row). Bar = 50 µm. (B) Ttransmission electron microscopy was applied to visualize changes in the organelles in cardiomyocytes (CMF, cardiac muscle fibers; Mi, mitochondria). Blue arrow represents break-up of myocardial fibers; red arrow represents mitochondrial changes of ferroptosis; and the yellow arrow represents expanded endoplasmic reticulum. Original magnification: ×12,000. Bar = 1 µm.
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    Fig. 8. ML385 eliminated the protective effects of notoginsenoside R1 in HAMI rats myocardial damage. (A) Myocardial injury was assessed by H&E staining (n=4). Blue arrow represents break-up of myocardial fibers; black arrow represents myocardial hemorrhage; and the green arrow represents inflammatory cells. Original magnification: ×20 (upper row); ×40 (lower row). Bar = 50 µm. (B) Ttransmission electron microscopy was applied to visualize changes in the organelles in cardiomyocytes (CMF, cardiac muscle fibers; Mi, mitochondria). Blue arrow represents break-up of myocardial fibers; red arrow represents mitochondrial changes of ferroptosis; and the yellow arrow represents expanded endoplasmic reticulum. Original magnification: ×12,000. Bar = 1 µm.

    Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Article Title: Notoginsenoside R1 treatment facilitated Nrf2 nuclear translocation to suppress ferroptosis via Keap1/Nrf2 signaling pathway to alleviated high-altitude myocardial injury.

    doi: 10.1016/j.biopha.2024.116793

    Figure Lengend Snippet: Fig. 8. ML385 eliminated the protective effects of notoginsenoside R1 in HAMI rats myocardial damage. (A) Myocardial injury was assessed by H&E staining (n=4). Blue arrow represents break-up of myocardial fibers; black arrow represents myocardial hemorrhage; and the green arrow represents inflammatory cells. Original magnification: ×20 (upper row); ×40 (lower row). Bar = 50 µm. (B) Ttransmission electron microscopy was applied to visualize changes in the organelles in cardiomyocytes (CMF, cardiac muscle fibers; Mi, mitochondria). Blue arrow represents break-up of myocardial fibers; red arrow represents mitochondrial changes of ferroptosis; and the yellow arrow represents expanded endoplasmic reticulum. Original magnification: ×12,000. Bar = 1 µm.

    Article Snippet: Dexamethasone (#S1322) and the Nrf2-specific inhibitor ML385 (#S8790) were obtained from Selleck Chemicals (Houston, TX, USA).

    Techniques: Staining, Electron Microscopy

    Fig. 9. ML385 eliminated the anti-ferroptosis of notoginsenoside R1 in HAMI rats myocardial damage. (A) Western blotting analysis of Keap1, GPX4, SLC7A11, FTH1, HO-1, and TFRC. (B) Effect of ML385 on Nrf2 localization in the nucleus and cytoplasm through Western blotting analysis. (C) Impacts of notoginsenoside R1 on GPX4 and Nrf2 levels was investigated using immunofluorescence staining. Red arrow represents nuclear translocation of Nrf2. Original magnification: ×20. Bar = 50 µm. The values are expressed as the means ± SEM (n = 7). ##P < 0.01, ###P < 0.001, and ####P < 0.0001 versus the HHM group; @@@P < 0.001 and @@@@P < 0.0001 versus the NR1 100 group.

    Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Article Title: Notoginsenoside R1 treatment facilitated Nrf2 nuclear translocation to suppress ferroptosis via Keap1/Nrf2 signaling pathway to alleviated high-altitude myocardial injury.

    doi: 10.1016/j.biopha.2024.116793

    Figure Lengend Snippet: Fig. 9. ML385 eliminated the anti-ferroptosis of notoginsenoside R1 in HAMI rats myocardial damage. (A) Western blotting analysis of Keap1, GPX4, SLC7A11, FTH1, HO-1, and TFRC. (B) Effect of ML385 on Nrf2 localization in the nucleus and cytoplasm through Western blotting analysis. (C) Impacts of notoginsenoside R1 on GPX4 and Nrf2 levels was investigated using immunofluorescence staining. Red arrow represents nuclear translocation of Nrf2. Original magnification: ×20. Bar = 50 µm. The values are expressed as the means ± SEM (n = 7). ##P < 0.01, ###P < 0.001, and ####P < 0.0001 versus the HHM group; @@@P < 0.001 and @@@@P < 0.0001 versus the NR1 100 group.

    Article Snippet: Dexamethasone (#S1322) and the Nrf2-specific inhibitor ML385 (#S8790) were obtained from Selleck Chemicals (Houston, TX, USA).

    Techniques: Western Blot, Immunofluorescence, Staining, Translocation Assay